Flux balance analysis is a mathematical approach for analyzing the flow of metabolites through a metabolic network. This primer covers the theoretical basis of the approach, several practical examples and a software toolbox for performing the calculations.
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Acknowledgements
This work was supported by National Institutes of Health grant no. R01 GM057089.
Author information
- Jeffrey D. Orth and Bernhard Ø. Palsson are at the University of California San Diego, La Jolla, California, USA., Jeffrey D Orth & Bernhard Ø Palsson
- Ines Thiele is at the University of Iceland, Reykjavik, Iceland., Ines Thiele
- Jeffrey D Orth